翻訳と辞書 Words near each other ・ HMNZS Kiwi (P3554) ・ HMNZS Kiwi (T102) ・ HMNZS Leander ・ Hmeida Ould Ahmed Taleb ・ Hmeinsein ・ Hmeljčič ・ HMF ・ HMF Engineering ・ HMFA Memorial Institute of Engineering and Technology ・ HMG ・ HMG Infosec Standard No.1 ・ HMG-box ・ HMG-CoA ・ HMG-CoA reductase ・ HMG-CoA reductase family ・ HMG-CoA synthase ・ HMG20A ・ HMG20B ・ HMGA ・ HMGA1 ・ HMGA2 ・ HMGB1 ・ HMGB2 ・ HMGB3 ・ HMGB4 ・ HMGCS2 ・ HMGN ・ HMGN1 ・ HMGN2 ・ HMGN3 Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク HMG-CoA synthase ： ウィキペディア英語版 HMG-CoA synthase In molecular biology, HMG-CoA synthase is an enzyme which catalyzes the reaction in which Acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). It is the second reaction in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is over-activated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis. ==Mechanism== HMG-CoA synthase contains an important catalytic cysteine residue that acts as a nucleophile in the first step of the reaction: the acetylation of the enzyme by acetyl-CoA (its first substrate) to produce an acetyl-enzyme thioester, releasing the reduced coenzyme A. The subsequent nucleophilic attack on acetoacetyl-CoA (its second substrate) leads to the formation of HMG-CoA. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HMG-CoA synthase」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.